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2018-01-05

Finding RCTs of new drugs: Searches in trial registries require specific adaptations

In their article in the Journal of Clinical Epidemiology, Marco Knelangen, Elke Hausner, Sibylle Sturtz, and Siw Waffenschmidt (all from the Institute for Quality and Efficiency in Health Care, IQWiG), as well as Maria-Inti Metzendorf (from the Cochrane Group at the Institute of General Medicine, University Hospital Düsseldorf), report on the availability of randomized controlled trials (RCTs) of newly approved drugs in trial registries. They also describe which specific search strategies yield reliable search results in the registries ClinicalTrials.gov (CT.gov), EU Clinical Trials Register (EU-CTR), and the WHO International Clinical Trials Registry Platform (ICTRP).
The results presented are based on a German-language working paper published by IQWiG in 2016 on searches in trial registries for studies of newly approved drugs.

Citation:

Knelangen M, Hausner E, Metzendorf MI, Sturtz S, Waffenschmidt S. Trial registry searches for RCTs of new drugs required registry-specific adaptation to achieve adequate sensitivity. J Clin Epidemiol 2018; 94: 69-75.


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