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The treatment effect on disease-free survival is not large enough to derive an effect on overall survival from it.
Compliance of pharma companies is relatively good, but very poor for university research groups. Research funders should make allocation of further funding dependent on data transparency.
Communicating evidence so that it reaches decision-makers, despite persistent prejudice and interest-driven interference: How does that work? We will discuss this on 23 and 24 November.
IQWiG still sees no basis for introducing a screening programme. There were neither comments on the preliminary report nor other new findings.
New guidelines change the results of the final report versus the preliminary report: Stronger focus, among other things, on the avoidance of hypoglycaemia by means of modern technologies.
TAILORx is the first available study with long-term follow-up suitable for the assessment. The Oncotype DX test apparently identifies women who can omit chemotherapy.
The treatment has been used in hospitals for over 20 years, and more than 100 studies have been completed worldwide. But manufacturers and researchers are concealing a large proportion of the results.
Less pain in stiff shoulders and improved mobility after total knee replacement – but the final report does not confirm greater benefit in rotator cuff tears.
In two early benefit assessments, IQWiG was unable to derive an added benefit from the data presented because current standards of care were not implemented in the studies.
NIPD can reduce the number of invasive tests and hence the number of test-related miscarriages in women whose foetuses are at an increased risk of trisomy 21.
IQWiG researchers involved in the early benefit assessment of palbociclib wrote a letter to the editor on the analysis of data from the PALOMA-2 study.
An update of the 2013 assessment shows that, due to a lack of suitable studies, data are missing for people with a family history of colorectal cancer.
The new non-invasive test, using a blood sample of the pregnant woman, is as reliable as the conventional test using a blood sample of the newborn. Studies on benefit and harm are still lacking.
The search update for a possible disease management programme “osteoporosis” showed that integrated concepts of medical and physical rehabilitation were hardly addressed.
An indication or hint of greater benefit was now shown for six instead of two therapeutic measures. This applies particularly to the attachment level.
If only 2 to 4 studies are available, meta-analyses often do not lead to informative results. However, suitable methods for evidence syntheses are available, even in the event of sparse evidence.
Regular use of fluoride varnish can prevent caries in primary teeth. Advantages or disadvantages regarding further patient-relevant outcomes remain unclear due to a lack of data.
Almost all health care aspects need to be updated. The already third search update for guidelines shows that their number and quality have increased notably in 10 years.
The first neurodermatitis drug undergoing the AMNOG procedure provides better symptom relief and has clear advantages particularly in the quality of life.
The data showed no relevant differences for some outcome criteria, and data were missing for others – also because some studies remain incompletely published.
Dr. Anna-Sabine Ernst
+49 221 35685-153
+49 221 35685-158
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