[A22-132] Zanubrutinib (chronic lymphocytic leukaemia, relapsed/refractory) – Benefit assessment according to §35a Social Code Book V

Last updated 15.03.2023

Project no.:
A22-132

Commission:
Commission awarded on 12.12.2022 by the Federal Joint Committee (G-BA).

Report type:
Dossier assessment

Status:
Commission completed

Department/Division:
Drug Assessment

Topic:
Cancer

Indication:

Patients with relapsed/refractory chronic lymphocytic leukaemia

Result of dossier assessment:
  • who have not yet received a Bruton tyrosine kinase (BTK) inhibitor and/or B-cell lymphoma-2 (BCL-2) inhibitor
    < 65 years: hint of major added benefit
    ≥ 65 years: hint of minor added benefit
  • after prior therapy with at least one BTK inhibitor: added benefit not proven
  • after prior therapy with at least one BCL-2 inhibitor: added benefit not proven
  • after prior therapy with at least one BTK inhibitor and one BCL-2 inhibitor: added benefit not proven
Note:

After completion of the assessment by IQWiG the Federal Joint Committee (G-BA) conducts a commenting procedure. This may provide supplementary information and as a result lead to a modified benefit assessment. Further information and the decision on the early benefit assessment can be found on the relevant page of the G-BA website.

Contact

Info Service (German)

Subscribe to daily updated information on projects, calls for tender, current vacancies and events as well as our press releases.

Register

Contact form

Questions about commissions, publications and press releases can be sent to us via this form.

Contact form